The usage of Commercial Off the Shelf (COTS) components can provide impactful benefits to space programs. Space programs can benefit by accessing the latest performance technology and shorten procurement times for faster pace programs. This ATR (Aerospace Technical Report) provides guidance for determining the risk (cost, schedule, technical) of inserting COTS components or units on space vehicles as well as potential best practices and mitigations for many known COTS component or unit concerns.