U.S. aspirations for continued leadership in space will require drawing from all sources of human creativity and inspiration. One important source is art, which can connect people and engage them in technological progress and scientific discovery. Art and space have connections going back to the early days of the space race. Creating art about space, for space, or even in space has helped propel both fields forward. This paper highlights the intersections between space and art—including some surprising ones—to demonstrate how art can be woven into U.S. space efforts for mutually beneficial outcomes.